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Randomized, Placebo-Controlled, Double-Blind Study Confirms Health Benefits of Hydrogen-water.

Japanese researchers studied subjects with muscle-affecting genetic disorders and find multiple benefits.

Researchers looked at patients with muscle diseases including progressive muscular dystrophy (PMD), four patients with polymyositis/dermatomyositis (PM/DM), and five patients with mitochondrial myopathies (MM). These disease are due to genetic errors and so there are essentially no good treatment options available for them. These conditions are some of the hardest diseases to treat. Despite this, researchers were able to provide these sufferers with some significant benefits without any adverse effect (save for those on insulin, see below). The patients experienced a lot of the same benefits that have described previously, adding more evidence to the benefits of consuming supersaturated hydrogen water. Check it out:

Depending on the study arm, subjects drank 1.5 or 3 twelve-ounce glasses (measured in liters) of hydrogen-water per day. They measured 18 serum parameters every 4 weeks. The study was over 4 or 8 weeks.

In the open-label trial, no objective improvement or worsening of clinical symptoms was observed which is mostly expected given the genetic nature of their problems. However significant effects in lactate-to-pyruvate ratios in PMD and MM, fasting blood glucose in PMD, serum matrix metalloproteinase-3 (MMP3) in PM/DM, and serum triglycerides in PM/DM. In the double-blind trial, no objective clinical effects were observed, but a significant improvement was detected in lactate in MM. Lactate-to-pyruvate ratios in MM and MMP3 in DM also exhibited favorable responses but without statistical significance. No adverse effect was observed in either trial except for hypoglycemic episodes in an insulin-treated MELAS patient, which subsided by reducing the insulin dose.

They concluded that hydrogen-enriched water improves mitochondrial dysfunction in MM and inflammatory processes in PM/DM. Less prominent effects with the double-blind trial compared to the open-label trial were likely due to a lower amount of administered hydrogen (0.5 instead of 1 liter) and a shorter exposure period, which implies a threshold effect or a dose-response effect of hydrogen.

They remind us that molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging activities that eliminate hydroxyl radical and peroxynitrite, and also to signal-modulating activities. Hydrogen is a safe molecule that is largely produced by intestinal bacteria in rodents and humans.

Bottom line: Apparently, even if you have a genetic disorder, drinking 3 glasses of hydrogen water per day can help reverse diabetes, lower triglycerides, reduce inflammatory markers (MMP3) and possibly avoid post-exercise soreness (lactate:pyruvate ratio). While almost every study documents how safe H2 supplementation is, this study highlights a concern with those using insulin to treat their diabetes and that the insulin dose may likely need to be reduced when starting supplementation.

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